Noonan Syndrome Presenting Growth Hormone Neurosecretory Dysfunction.
نویسندگان
چکیده
منابع مشابه
Growth Hormone Deficiency in a Child with Neurofibromatosis-Noonan Syndrome.
Neurofibromatosis-Noonan syndrome (NFNS) is a distinct entity which shows the features of both NF1 (neurofibromatosis 1) and Noonan syndrome (NS). While growth hormone deficiency (GHD) has been relatively frequently identified in NF1 and NS patients, there is limited experience in NFNS cases. The literature includes only one case report of a NFNS patient having GHD and that report primarily foc...
متن کاملShort stature in Noonan syndrome: response to growth hormone therapy.
BACKGROUND Growth hormone (GH) has been used to promote growth in both the short and long term in a number of dysmorphic syndromes, including Turner syndrome. As this condition shares many clinical features with Noonan syndrome, it would seem logical to treat the latter group with GH. AIMS To assess the short and long term response to GH therapy in patients with Noonan syndrome. METHODS Ana...
متن کاملClinical evaluation of recombinant human growth hormone in Noonan syndrome.
The objective of this study was to investigate the effect of administration of recombinant human growth hormone (hGH) in patients with Noonan syndrome. hGH was administered (0.5 IU/kg/week) to 15 patients with Noonan syndrome over a 2 year period. Average patient age prior to therapy was 7.5 +/- 2.5 (mean +/- SD) yr, the height SD score was -2.8 +/- 0.7, and the pretreatment height velocity and...
متن کاملFive-year response to growth hormone in children with Noonan syndrome and growth hormone deficiency
BACKGROUND Noonan syndrome (NS) is an autosomal dominant disorder characterized by specific features including short stature, distinctive facial dysmorphic features, congenital heart defects, hypertrophic cardiomyopathy, skeletal anomalies and webbing of the neck. Molecular screening has shown that the majority of individuals with NS have a mutation in the PTPN11 gene. Noonan syndrome children ...
متن کاملShort stature due to growth hormone neurosecretory dysfunction in a child with major depressive disorder.
Literature indicating clinical growth hormone deficiency due to depression is extremely limited, despite a well-known impaired basal and/or stimulated growth hormone secretion in depressive disorders. In this communication, we present a case of short stature due to growth hormone neurosecretory dysfunction in a nine year old girl with major depressive disorder.
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ژورنال
عنوان ژورنال: Internal Medicine
سال: 1992
ISSN: 0918-2918,1349-7235
DOI: 10.2169/internalmedicine.31.908